In the following paragraphs, we want to discuss mechanisms employed by tumour cells to hide from immune recognition and promote their in vivo survival and progression. Particular attention will be given to the ability of tumour cells to secrete small vesicles (known as exosomes or microvesicles) gathering a still growing number of immunosuppressive and modulating functions. The possibility of interfering by pharmacological intervention with their formation and release process, and the theoretical benefits of this strategy for cancer patients, are also addressed..

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